Depo-Provera 150mg

Description

DEPO-PROVERA 150mg is a long-acting contraceptive injection containing 150 mg of medroxyprogesterone acetate per 1 ml of suspension. It is primarily used for long-term contraception but can also be used in specific short-term circumstances. It is important for potential users to receive comprehensive counseling about the product’s long-term nature, possible side effects, and the inability to reverse the effects immediately after injection.

Key Ingredients:

• Active Ingredient: Medroxyprogesterone acetate (150 mg/ml)
• Excipients with Known Effect:
  • Methyl parahydroxybenzoate (E218) – 1.35 mg
  • Propyl parahydroxybenzoate (E216) – 0.15 mg
  • Sodium chloride – 3.38 mg/ml

Indications for Use:

1. Primary Use: Long-term contraception for women.
2. Short-term Contraception in Specific Circumstances:
   • For partners of men undergoing vasectomy until the vasectomy becomes effective.
   • For women being immunized against rubella to prevent pregnancy during the period of virus activity.
   • For women awaiting sterilization.

Administration Guidelines:

1. Initial Injection:
   • Administer 150 mg of DMPA by intramuscular (IM) injection in the gluteal or deltoid muscle.
   • Timing:
     • During the first 5 days after the onset of a normal menstrual period.
     • Within 5 days postpartum if not breastfeeding.
     • At or after 6 weeks postpartum if exclusively breastfeeding.
2. Subsequent Injections:
   • Administer every 3 months (12-13 weeks).
   • If the interval between injections exceeds 13 weeks, ensure the patient is not pregnant before administering the next injection.

Important Considerations:

• Pregnancy Test: Ensure a negative pregnancy test before the first administration.
• Bone Mineral Density (BMD): Long-term use may lead to loss of BMD; a risk/benefit assessment is essential, especially considering natural BMD decreases during pregnancy and lactation.
• Counseling: Provide thorough explanations about the long-term nature, possible side effects, and the non-reversible effects of each injection. Utilize patient information leaflets for effective counseling.
• Examinations: Conduct a general medical and gynecological examination before the initial administration and at yearly intervals thereafter.

Side Effects and Contraindications:

• Side Effects:
  • Heavy or prolonged bleeding
  • Bone mineral density loss
  • First-time migraines or unusually severe headaches
  • Visual disturbances
  • Reappearance of depression
  • Pathological changes in liver function tests
• Contraindications: Use with caution in the puerperium due to the risk of heavy or prolonged bleeding.

Storage Instructions:

• Store the pre-filled syringe under recommended conditions, avoiding freezing.

Patient Follow-Up:

• Regular Monitoring: Consider regular follow-up to monitor for side effects and overall health, especially concerning migraines, visual disturbances, depression, and liver function tests.

Conclusion: DEPO-PROVERA 150mg is an effective contraceptive method that requires careful consideration and patient counseling due to its long-term effects and potential side effects. Adhering to administration guidelines and regular monitoring can help manage and mitigate risks associated with its use.